This research is part of the European ENVISION project (European NoVel Imaging Systems for ION therapy) where many European partners are investigating ion particle dosimetry and in-­vivo dose verification. Our work within the ENVISION project is a joint venture between the Maastro Clinic and the Gray Institute for Radiation Oncology and Biology, with close collaboration of the Medical University of Vienna: Division of Medical Radiation Physics.

The potential clinical effect on the dose distribution due to errors in beam delivery, patient changes, etc, is a subject of great interest. Emphasis is especially focused on the prediction of treatment outcome through radiobiological models based on these dose distributions and the clinical effect of these errors.

The work involves sensitivity analyses of humanoid and more abstract geometry cases and is partly embedded in the in silico trial group ROCOCO (Radiation Oncology COllaborative COmparison).